Are varicose veins a warning sign of potentially deadly clots?

  • Are varicose veins a warning sign of potentially deadly clots?

Are varicose veins a warning sign of potentially deadly clots?

They say further research is needed to determine whether varicose veins can cause DVT or whether they simply share similar risk factors.

Varicose veins are swollen and broadened veins that more often than not happen on the legs and feet. Chang hypothesized that since patients with varicose veins have increased inflammation, the inflammatory processes may cause abnormal blood clotting.

Adults with varicose veins carry increased risk of incident deep vein thrombosis (DVT), according to a large, population-based cohort study. The HR for the association of varicose veins with PE was 1.73 (95% CI 1.54-1.94) compared with the control group. However, Chen noted that her team is now undertaking another study to better understand how those treatments could mitigate the risk of the 3 conditions. Animal models have shown higher concentrations of macrophages, monocytes, neutrophils, lymphocytes, and matrix metalloproteinases in venous valves exposed to high pressure for prolonged periods, like in varicose veins.

"Patients with varicose veins have increased incidence of inflammatory and prothrombotic markers", the researchers wrote.

Important to the study design was the fact that the three endpoints were analyzed separately, i.e., if a patient with DVT later developed PE or PAD, these were counted as cases in the analysis of the other endpoint (s).

Median follow-up was between 7 and 8 years for each group and outcome. Yet "fewer studies have established an association between varicose veins and peripheral arterial disease", he said.

Varicose veins are a common, but a new study has warned the little blue veins, previously thought to be harmless, can be quite risky for your health. "Due to the strong relationship between varicose veins and the increased risk of more serious disease, patients with varicose veins deserve careful monitoring and early evaluation". But when researchers in Taiwan looked at data on more than 400,000 people.

Disclosures: The authors report no relevant financial disclosures.