Breakthrough: Nanotechnology Regenerates Cells of any Kind

  • Breakthrough: Nanotechnology Regenerates Cells of any Kind

Breakthrough: Nanotechnology Regenerates Cells of any Kind

Says Sen: "By using our novel nanochip technology, injured or compromised organs can be replaced".

Researchers also said that the TNT is not limited on skin cells.

Researchers from Ohio State University call the new technology tissue nanotransfection (TNT).

In less than a second, this chip would deliver reprogramming factors (pre-programmed DNA or RNA) non-invasively into living skin cells via a high-intensity, focused electric field, converting them into whatever type of cells a scientist or doctor may choose.

Chandan Sen director for the Center for Regenerative Medicine and Cell-Based Therapies declared that TNT can actually restore any type of tissues, not only skin cells.

By the second week, active blood vessels had formed, and by the third week, the legs of the mice were saved-with no other form of treatment.

By using mice and pigs in conducting experiments, the researchers were able to reprogram skin cells to become vascular cells in a leg that lacked blood flow due to injury.

This breakthrough technology is the first time cells have been reprogrammed in a live body.
"We are proposing the use of skin as an agricultural land where you can essentially grow any cell of interest", he said. The cargo is delivered by zapping the device with a small electrical charge that's barely felt by the patient.

In a series of lab tests, researchers from Ohio State University Wexner Medical Center applied the chip to the injured legs of mice that vascular scans showed had little to no blood flow. There were no side effects reported with the treatment, which also was used to grow brain cells in mice who suffered strokes.

TNT is a nanotechnology-based chip created to deliver cargo to adult cells in the body and the design of specific biological cargo for cell conversion. Through this process, the DNA will be converted to the specific building block cells of the damaged body part.

"The concept is very simple", Lee said. The team said they were "surprised" it worked so well.

It doesn't require laboratory-based procedures, is non-invasive and can me implemented at the point of care. For a long time researchers have tried to come up with a mechanism that could treat and even fix brain injuries.

The researchers still wait for FDA approval and for the first time in four years since they started the project, the researchers will be able to test TNT on humans.