Chemical In Broccoli May Lower Blood Sugar Of Diabetes Patients

  • Chemical In Broccoli May Lower Blood Sugar Of Diabetes Patients

Chemical In Broccoli May Lower Blood Sugar Of Diabetes Patients

A powder that contains broccoli extract has the potential to treat people with type 2 diabetes, a study has found.

For the study, the researchers - led by Annika Axelsson - observed 97 individuals who were diagnosed with type 2 diabetes. Those who didn't take metformin were able to control their condition relatively well without it.

This study showed that metformin and sulphoraphane lower blood glucose in different ways: metformin makes cells sensitive to insulin, so more glucose is passed out of the bloodstream, while sulphoraphane helps to suppress the production of glucose.

"Sulforaphane targets a central mechanism in type 2 diabetes and has a mild side-effect profile".

Many people with diabetes have a tough time keeping their blood sugar well-controlled, said Dr. Robert Courgi, an endocrinologist at Northwell Health's Southside Hospital, in Bay Shore, N.Y. The blood sugar of the animals that received sulforaphane dropped by 23 percent in four weeks, and by 24 percent in those given metformin. They are also applying to regular authorities to seek approval for the powder that could take two years.

Type 2 diabetes affects around 450 million people worldwide and as many as 15 percent of those patients can not take the first-line therapy metformin because of kidney damage risks.

The researchers constructed a signature for type 2 diabetes based on 50 genes. Most other diabetes drugs work by managing insulin levels.

Among the participants, only three people continued taking metformin.

The American Diabetes Association suggests an A1C goal of 7 percent for most people with diabetes - though some may need a higher or lower goal.

Professor Neal said: "We don't know why there was an increased risk of amputation, and further work is needed in this area".

"To conclude that broccoli or broccoli sprouts is the answer to diabetes control would be mistaken", said Sharon Movsas.

According to Rosengren, a person would have to eat more than a plateful of broccoli each day to get the amount of sulforaphane used in this study. "Sulforaphane suppressed glucose production from hepatic cells by nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) and decreased expression of key enzymes in gluconeogenesis", the researchers noted.

However, he added, "increasing your daily intake of broccoli could certainly be good from many viewpoints".

The publication in the journal Science Translational Medicine builds on several years' research at Sahlgrenska Academy and Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, and the Faculty of Medicine at Lund University.